Table 3. Absolute incidence rate difference between IBS cases and controls for each disease stratified by current age and time since IBS diagnosis.

Current age	Time since IBS diagnosis	Coeliac disease		IBD		CRC
		Absolute rate difference (per 10000 person years)	95% CI	Absolute rate difference (per 10000 person years)	95% CI	Absolute rate difference (per 10000 person years)	95% CI
18–29	0–6 months	15.10	4.83–16.45	66.25	51.66–80.84	3.14	0.06–6.23
	6–12 months	7.20	0.43–9.22	38.26	26.20–50.33	0.90	−0.86–2.66
	1–5 years	4.00	1.46–4.71	18.51	14.35–22.67	−0.57	−1.03– −0.12
	5–10 years	3.60	−0.87–6.51	12.62	5.26–19.99	-	-
	10 years to end of follow-up	-	-	9.62	−4.99–6.91	-	-
30–49	0–6 months	17.40	9.34–19.38	55.21	45.45–64.98	17.44	10.07–22.80
	6–12 months	4.70	1.66–7.98	32.39	24.61–40.16	3.93	1.18–6.67
	1–5 years	2.60	1.34–3.35	11.73	9.72–13.74	0.94	0.18–1.69
	5–10 years	2.40	0.13–2.60	4.87	2.83–6.91	0.05	−0.79–0.89
	10 years to end of follow-up	1.10	−0.51–3.05	5.88	2.49–9.27	−0.26	−1.96–1.44
50–74	0–6 months	11.7	6.4–16.9	39.52	29.88–49.16	83.46	69.09–97.84
	6–12 months	4.7	0.8–8.5	16.93	10.09–23.78	24.65	15.56–33.76
	1–5 years	3.1	1.8–4.4	9.75	7.61–11.90	2.69	0.50–4.89
	5–10 years	2.7	1.3–4.0	6.49	4.40–8.59	0.37	−4.85–2.59
	10 years to end of follow-up	2.8	0.8–4.8	3.94	1.57–6.31	−1.09	−4.14–1.95
75 and older	0–6 months	-	-	-	-	94.64	−939.23–496.49
	6–12 months	-	-	-	-	-	-
	1–5 years	−0.8	−3.9–2.3	6.14	−2.85–15.14	−4.59	−17.97–0.78
	5–10 years	2.0	−0.1–4.9	3.21	−1.79–8.21	4.58	−6.34–15.54
	10 years to end of follow-up	2.4	−1.5–6.3	5.06	0.05–10.10	−1.76	−12.01–8.49

Rates in bold are statistically significant with a p-value <0.05 The absolute rate difference indicates how many additional people would be expected to be diagnosed with each condition in a group with IBS, rather than the proportional difference that is presented in the rate ratio measure.