Table 4. OR and 95% CIs of age and sex adjusted and fully adjusted conditional regression models for genetic ancestry fractions and known risk factor of colorectal adenoma and adenocarcinoma.

	Adenoma			Adenocarcinoma
Characteristic	OR	95% CI	P-values	OR	95% CI	P-values
Age- and sex-adjusted model
African ancestry
Risk variation per 10% increase	1.13	(0.99, 1.27)	0.06	1.18	(1.06, 1.31)	0.001
P for trend		0.09			0.002
European ancestry a
Risk variation per 10% increase	1.25	(1.08, 1.46)	0.001	0.98	(0.88, 1.10)	0.79
P for trend		0.0004			0.91
Fully adjusted model
African ancestry	Ref	−		Ref	−
Risk variation per 10% increase	1.12	(0.97, 1.30)	0.15	1.19	(1.05, 1.35)	0.006
P for trend		0.08			0.003
European ancestry b
Risk variation per 10% increase	1.25	(1.08, 1.46)	0.007	1.02	(0.90, 1.16)	0.75
P for trend		0.001			0.68
Education attained
None	0.77	(0.11, 5.24)	0.79	2.56	(0.89, 7.36)	0.08
Primary school	Ref	−		Ref	−
Secondary	1.5	(0.74, 3.06)	0.26	0.77	(0.45, 1.30)	0.4
College	2.11	(0.78, 5.75)	0.14	0.55	(0.23, 1.31)	0.23
University	3.82	(1.59, 9.17)	0.01	1.03	(0.60, 2.52)	0.95
Colorectal cancer family history c
Yes	1.73	(0.60, 5.02)	0.83	1.72	(0.67, 4.40)	0.74
Alcohol intake (g/day) c
<12.5	0.65	(0.30, 1.44)	0.29	1.08	(0.56, 2.07)	0.82
12.5	0.86	(0.40, 1.83)	0.69	0.97	(0.48, 1.94)	0.92
Smoking (packs/years)
<0.5	Ref	−		Ref	−
0.5–0.9	0.65	(0.30, 1.44)	0.29	1.08	(0.56, 2.07)	0.82
1	0.86	(0.40, 1.83)	0.69	0.97	(0.48, 1.94)	0.92
Red meat (times/week)
<2	Ref	−		Ref	−
2–4	0.87	(0.41, 1.84)	0.71	1.34	(0.67, 2.67)	0.41
5	0.84	(0.37, 1.88)	0.67	1.66	(0.80, 3.42)	0.17
Energy intake (quartile)
Q1	Ref	−		Ref	−
Q2	0.81	(0.35, 1.88)	0.62	0.64	(0.31, 1.33)	0.23
Q3	1.21	(0.49, 2.99)	0.69	0.68	(0.30, 1.52)	0.34
Q4	1.36	(0.51, 3.65)	0.54	0.44	(0.18, 1.08)	0.09
NSAID
Yes	0.6	(0.29, 1.21)	0.15	0.93	(0.52, 1.66)	0.82
Dietary fiber (quartile)
Q1		1
Q2	0.81	(0.35, 1.88)	0.62	0.64	(0.31, 1.33)	0.23
Q3	1.21	(0.49, 2.99)	0.69	0.68	(0.30, 1.52)	0.34
Q4	1.36	(0.51, 3.65)	0.54	0.44	(0.18, 1.08)	0.07
Physical activity (IPAQ categories)
Low
Moderate	0.67	(0.34, 1.32)	0.24	0.77	(0.43, 1.37)	0.37
High	0.76	(0.37, 1.54)	0.44	0.89	(0.50, 1.60)	0.7

Abbreviations: CI, confidence interval; IPAC, International Physic Activity Questionnaire; NSAID, nonsteroidal anti-inflammatory drug; OR, odds ratio.

^aEuropean ancestry substitution effect (European−Amerindian ancestry) adjusted only for age, sex and city of enrollment.

^bEuropean ancestry substitution effect (European−Amerindian ancestry) adjusted for age, sex, city of enrollment and all other factors listed.

^cAbsence of the exposure considered as reference value.