Table 6. Multivariate analysis of variables for prediction of SVR in GT2 and GT3.
Genotype 2 | Genotype 3 | |||||||
Baseline variables in patients with complete data available * | p | OR | 95% CI for OR § | p | OR | 95% CI for OR § | ||
Age ≤45 years vs.>45 years | 0.001 | 0.613 | 0.460 | 0.817 | ||||
Cholesterol ≤130 vs.>130 mg/dl | 0.001 | 1.768 | 1.277 | 2.446 | ||||
γ-GT (U/l)> vs. ≤3 time ULN | 0.011 | 0.341 | 0.148 | 0.785 | 0.030 | 0.585 | 0.361 | 0.950 |
APRI score <0.5. 0.5 - ≤1.5. 1.5 - ≤2 | 0.269 | 0.002 | 0.786 | 0.673 | 0.917 | |||
HCV-RNA ≤400,000 vs.>400,000 IU/ml | 0.780 | |||||||
Psychiatric co-morbidity | 0.165 | |||||||
Variables under treatment in patients with complete data * | ||||||||
RVR | 0.000 | 3.770 | 1.930 | 7.362 | 0.001 | 1.63 | 1.212 | 2.203 |
Ribavirin starting dose (mg/kg body weight) | 0.256 | 0.006 | 1.069 | 1.208 | 2.198 |
* For GT3 complete baseline data for multivariate analysis were available for 968 patients and in 341 patients with GT2; complete data under treatment were available for 787 patients with GT3 and for 180 patients with GT2.
OR = Odds Ratio; CI = Confidence interval.