Table 1. Cytokine genes associated with different diseases as reported in previous studies.

Gene	SNP	Chromosomal location	Diseases
IL1A−889	rs1800587	2q14	Irritant contact dermatitis [61]
IL1B−511	rs16944	2q14	Susceptibility to asthma [62]
IL1B+3962	rs1143634	2q14	Chronic periodontitis [63]
IL1R1970	rs2234650	2q14	Pulmonary tuberculosis [64]
IL1RA 11100	rs315952	2q14.2	Systemic lupus erythematosus[65]
IL4RA +1902	rs1801275	16p12.1-p11.2	Eczema [66]
IL12 −1188	rs3212227	5q31.1-q33.1	Asthma [67]
IFNG +874	rs2430561	12q14	Severe acute respiratory syndrome [68]
TGFB1 codon 10	rs1982073	19q13.1	Chronic obstructive pulmonary disease [69]
TGFB1 codon 25	rs1800471	19q13.1	Dust mite exposure and disease severity in children with asthma [70]
TNFA −308	rs1800629	6p21.3	Chronic irritant contact dermatitis [50]
TNFA −238	rs361525	6p21.3	Chronic rhinosinusitis[71]
IL2 −330	rs2069762	4q26-q27	Allergic disorders [53]
IL2 +166	rs2069763	4q26-q27	Lupus erythematosus; type 1 diabetes; cancer risk [72], [73], [74]
IL4 −1098	rs2243248	5q31.1	Allergic rhinitis and association with clinical phenotypes [75]
IL4 −590	rs2243250	5q31.1	Atopic asthma and allergic rhinitis; asthmatic children [57], [76]
IL4 −33	rs2070874	5q31.1	Atopic asthma and allergic rhinitis [57]
IL6 −174	rs1800795	7p21	Hypertension; type 2 diabetes; systemic-onset juvenile chronic arthritis [77], [78], [79]
IL6 nt565	rs1800797	7p21	Coronary artery disease [80]
IL10 −1082	rs1800896	1q31-q32	Dust mite exposure in allergy and asthma exacerbations; food allergy [43], [81]
IL10 −819	rs1800871	1q31-q32	Inflammatory and infectious respiratory diseases [82]
IL10 −592	rs1800872	1q31-q32	Cow's milk allergy [83]

SNP  =  single nucleotide polymorphism.