Table 3. Proteomic results: increased.
Accession | Gene Symbol | Protein description | KO/WT |
Protein synthesis | |||
P60843 | Eif4a1 | Eukaryotic initiation factor 4A–I | 99.083 |
P62849 | Rps24 | 40 S ribosomal protein S24 | 36.644 |
P62908 | Rps3 | 40 S ribosomal protein S3 | 9.036 |
P14148 | Rpl7 | 60 S ribosomal protein L7 | 5.495 |
P47963 | Rpl13 | 60 S ribosomal protein L13 | 1.770 |
Protein/amino acid catabolism | |||
P46471 | Psmc2 | 26 S protease regulatory subunit 7 | 83.176 |
Q9QXF8 | Gnmt | Glycine N-methyltransferase | 4.285 |
Q8QZR5 | Gpt | Alanine amino transferase 1 | 1.820 |
Carbohydrate catabolism | |||
A2AJL3 | Fggy | FGGY carbohydrate kinase domain containing protein | 84.723 |
Q91×44 | Gckr | Glucokinase regulatory protein | 1.977 |
Electron transfer/energy production | |||
P03930 | Mtatp8 | ATP synthase protein 8 | 9.462 |
Q9D0M3 | Cyc1 | Cytochrome c1 | 6.668 |
Biotransformation/xenobiotics metabolism | |||
P24456 | Cyp2d10 | Cytochrome P450 2D10 | 11.803 |
P37040 | Por | NADPH–cytochrome P450 reductase | 7.447 |
Q9DBG1 | Cyp27a1 | Sterol 26-hydroxylase | 4.656 |
Q9DCM2 | Gstk1 | Glutathione S-transferase kappa 1 | 3.467 |
Hepatocyte structure maintenance | |||
P11679 | Krt8 | Keratin, type II cytoskeletal 8 | 12.474 |
P05784 | Krt18 | Keratin | 5.649 |
Transport/signaling/chromosome | |||
Q00724 | Rbp4 | Retinol-binding protein 4 | 84.723 |
P29391 | Ftl1 | Ferritin light chain 1 | 9.727 |
P60766 | Cdc42 | Cell division control protein 42 homolog | 2.938 |
Q64374 | Rgn | Regucalcin | 1.542 |
P62806 | Hist1h4a | Histone H4 | 4.699 |
The proteins whose levels are increased in CYP2E1 knockout versus wild type (WT) mice and directly related to carbohydrate, protein or amino acid catabolism, or biotransformation are listed. The relative protein expression level in knockout versus wild-type mice (KO/WT) is shown.