Figure 7. The effects of Ast IV and 2-MeOE2post-ischemia treatment on HIF-1α, iNOS, Bcl2, and Caspase3 protein expression in IR-injured isolated hearts.

(A). Representative images of HIF-1α and iNOS expression are shown. (B). Representative images of Bcl2 and Caspase3 expression are shown. The results are expressed as the mean±SEM, n = 6. ^aaP<0.01 vs. Control; ^bbP<0.01 vs. IR; ^ccP<0.01 vs. IR+Ast IV. IR, ischemia reperfusion; Ast IV, Astragaloside IV; 2-MeOE2, 2-methoxyestradiol.