Table 2.
Meta-analysis results of three genome-wide association studies for total lung capacity measured by CT in COPD subjects *
| Locus | SNP | Nearest Gene | Distance (kb) | Risk/Non-risk Allele | FRQ | COPDGene NHW | ECLIPSE | GenKOLS | Overall | I 2 | Q | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| β | P | β | P | β | P | β | P | ||||||||
| 5p15.2 | rs114929486 | DNAH5 | 0 | A/G | 0.04 | 0.37† | 2.94 × 10−4 | 0.60† | 7.18 × 10−6 | 0.13† | 5.47 × 10−1 | 0.42 | 4.66 × 10−8 | 49 | 0.14 |
| 8q24.12 | rs10955930 | ENPP2 | 30 | T/A | 0.49 | 0.11† | 5.55 × 10−4 | 0.15† | 1.19 × 10−3 | 0.22† | 7.45 × 10−3 | 0.13 | 1.38 × 10−7 | 0 | 0.37 |
| 19p13.12 | rs590950 | CYP4F8 | 26 | T/C | 0.49 | 0.13† | 3.36 × 10−6 | 0.09† | 3.79 × 10−2 | 0.13† | 1.25 × 10−1 | 0.12 | 1.39 × 10−7 | 0 | 0.72 |
| 6q13 | rs72920744 | B3GAT2 | 6 | G/A | 0.99 | 0.40† | 8.05 × 10−3 | 0.83† | 6.32 × 10−6 | 0.61† | 1.11 × 10−1 | 0.58 | 2.18 × 10−7 | 39 | 0.19 |
| 8q24.3 | rs57629580 | LY6H | 35 | C/A | 0.91 | 0.30† | 1.47 × 10−5 | 0.27† | 4.02 × 10−3 | 0.10† | 6.05 × 10−1 | 0.28 | 2.56 × 10−7 | 0 | 0.66 |
Definition of abbreviations: FRQ = risk allele frequency; NHW = non-Hispanic white; SNP = single nucleotide polymorphism.
*Adjusted for age, sex, height, pack-years of cigarette smoking and genetic ancestry as summarized in the principal components.
†Imputed genotypes.