Table 3.
Mean total lung capacity measured by CT (TLC CT ) according to genotype of rs114929486 in DNAH5 (N = 4,543) *
rs114929486 | GG | AG | P | |
---|---|---|---|---|
All | N | 4282 | 258 | |
TLCCT, L | 6.12 (1.41) | 6.50 (1.52) | 0.0001 | |
COPDGene | n | 2531 | 121 | |
TLCCT, L | 6.18 (1.40) | 6.47 (1.47) | 0.042 | |
ECLIPSE | N | 1364 | 99 | |
TLCCT, L | 6.15 (1.42) | 6.84 (1.57) | 1.96 × 10-5 | |
GenKOLS | N | 387 | 38 | |
TLCCT, L | 5.56 (1.30) | 5.70 (1.25) | 0.486 |
Data are presented as mean (SD).
*Three subjects with AA genotype (each one from each cohort) were excluded from this analysis.