Table 1.

Definition of limited antineoplastic treatment options

Disease	Limited treatment options
Breast cancer	Refractory to 3rd line antineoplastic treatment for metastatic disease
Lung cancer	Refractory to 1st line chemotherapy for metastatic/advanced disease
Gastrointestinal cancers	Refractory to 1st line chemotherapy for metastatic/advanced disease
Ovarian cancer/Uterine cancer	Refractory to 2nd line chemotherapy for metastatic/advanced disease
Cervical cancer/Vulva cancer	Refractory to 1st line chemotherapy for metastatic/advanced disease
CNS tumors	Refractory to concomitant/adjuvant chemotherapy
Prostate cancer/Bladder cancer/Penile cancer/Thyme cancer/Adrenal carcinomas	Refractory to 1st line chemotherapy for metastatic/advanced disease
Cancer of Unknown Primary origin (CUP)	Refractory to 1st line chemotherapy for metastatic/advanced disease
Head and neck cancer	Refractory to radiation therapy or surgery with curative intention