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Comparison of the piperacillin and tazobactam exposures in the plasma (left) and ELF (center), as well as the plasma: ELF ratio (right). The dotted lines illustrate the 8:1 ratio of piperacillin to tazobactam in the administered piperacillin 4.0 g/tazobactam 0.5 g preparation. AUC, area under the concentration–time curve; ELF, epithelial lining fluid.
