TABLE 3.
Unadjusted and multivariable-adjusted associations of patient characteristics with frailty: ACTIVE-ADIPOSE hemodialysis cohort
| Classified as Frail | ||
|---|---|---|
| Characteristics | Unadjusted OR (95% CI) | a Adjusted OR (95% CI) |
| Race | ||
| White (reference) | 1.00 | 1.00 |
| Black | 0.51 (0.32, 0.82)b | 0.58 (0.34, 0.99)b |
| Other | 0.70 (0.37, 1.34) | 0.63 (0.30, 1.33) |
| Gender | ||
| Male (reference) | 1.00 | 1.00 |
| Female | 1.11 (0.73, 1.69) | 0.88 (0.54, 1.45) |
| Age ≥ 65 | 2.47 (1.61, 3.78)d | 1.61 (0.97, 2.68) |
| At least high school education | 0.65 (0.42, 1.03) | 0.67 (0.39, 1.13) |
| Diabetes | 1.79 (1.17, 2.75)c | 1.39 (0.83, 2.35) |
| COPD | 1.62 (0.83, 3.17) | 0.86 (0.38, 1.91) |
| CHF | 1.80 (1.17, 2.76)c | 1.21 (0.72, 2.03) |
| CAD/MI | 1.79 (1.16, 2.78)c | 0.81 (0.46, 1.43) |
| CVA/TIA | 2.27 (1.29, 3.99)c | 1.78 (0.89, 3.54) |
| PVD | 3.74 (2.17, 6.44)d | 2.28 (1.17, 4.44)b |
| Other cardiac diseases | 2.70 (1.76, 4.15)d | 1.90 (1.09, 3.31)b |
| BMI | ||
| <18.5 | 1.51 (0.41, 5.57) | 1.25 (0.27, 5.78) |
| [18.5, 25] (reference) | 1.00 | 1.00 |
| [25, 30] | 0.93 (0.54, 1.59) | 0.79 (0.43, 1.46) |
| ≥ 30 | 1.18 (0.72, 1.94) | 1.02 (0.57, 1.81) |
| Hemoglobin | 0.83 (0.71, 0.98)b | 0.92 (0.76, 1.11) |
| Serum albumin | 0.14 (0.08, 0.24)d | 0.18 (0.10, 0.34)d |
| Serum bicarbonate | 1.07 (1.01, 1.14)b | 1.01 (0.94, 1.09) |
| Serum phosphate | 0.89 (0.78, 1.02) | 0.98 (0.83, 1.15) |
| ESRD therapy ≤1 year | 1.39 (0.84, 2.31) | 1.08 (0.60, 1.96) |
a
N= 727 participants with information for all covariates.
b
P < 0.05.
c
P < 0.01.
d
P < 0.001.
BMI indicates body mass index; CAD, coronary artery disease; CHF, congestive heart failure; CI, confidence interval; COPD, chronic obstructive pulmonary disease; CVA, cerebrovascular accident; MI, myocardial infarction; other cardiac disease, cardiac dysrhythmia, atrial fibrillation, tachycardia, pericarditis, cardiac arrest; OR, odds ratio; PVD, peripheral vascular disease; TIA, transient ischemic attack.