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. Author manuscript; available in PMC: 2015 Oct 1.
Published in final edited form as: J Hepatol. 2014 May 22;61(4):903–911. doi: 10.1016/j.jhep.2014.05.024

Figure 2. Hsp90 inhibition using 17-DMAG alleviates acute and chronic alcohol induced liver injury.

Figure 2

Figure 2

Bioavailability of 17-DMAG (A) was assayed by LC-MS/MS in liver. Serum ALT (B) and liver triglycerides (C) analyzed in acute alcohol and 17-DMAG administered mice. Serum ALT (D), liver triglycerides (E), histology (F) and Oil Red O staining (G) were investigated in mice fed chronic-binge alcohol and treated with 17-DMAG at the end of the feeding. Bar graph (G) shows relative density of lipids measured using ImageJ software. 17-DMAG administered every alternate day during alcohol feeding and serum ALT (H) and liver triglycerides (I) analyzed. Bars represent mean ± SE, (n=6). **p<0.05, *p<0.0005, #p<0.00005.