Table 1.

Recruitment sites and patient enrollment for the eMERGE-PGx project

Site	Participant Pool	Participant Selection Method	Target Enrollment
Boston Children’s Hospital (BCH)	Patients (inpatient and clinic) followed by the anticoagulation service	Participants 1 month of age or older who will potentially require warfarin	250
Children’s Hospital of Philadelphia (CHOP)	The entire hospital and outpatient clinics	Participants taking more than 3 medications at once, EHR records for serious adverse event (SAE), SAE noted during hospitalization	1650
Cincinnati Children’s Hospital Medical Center (CCHMC)	Pediatric general surgery, thoracic surgery, and orthopedic surgery clinics	6–21 year olds being evaluated for pectus excavatum or scoliosis	375
	Past participants in tonsillectomy studies	Participants 6–15 years old	300
Geisinger Health System (GHS)	MyCode™ biobank participants	All males over the age of 50 who were not on one of more of the target medications at the time of ascertainment	1100
Group Health/University of Washington	Northwest Institute of Genetic Medicine (NWIGM) biorepository participants	Adults aged 50–65 years old at the time of entry to the repository indicating interest in return of clinically useful results. Preferential selection for individuals with certain diagnoses and medication history and all participants with Asian or African American descent.	900
Marshfield Clinic	Adults above the age of 50 with a primary care physician in the Marshfield Clinic.	Adults above the age of 50 with no prior use of simvastatin, warfarin or clopidogrel	750
Mayo Clinic	Mayo Clinic Biobank participants who are adult primary care patients	Predictive regression algorithm to estimate risk of receiving statin therapy	1000
Icahn School of Medicine at Mount Sinai	Patients with primary care providers at Mount Sinai Faculty Practice Associates—Primary Care Associates	Adults above the age of 50 with no prior use of simvastatin, warfarin, or clopidogrel	750
Northwestern University	Patients visiting the Northwestern Medical Group-General Internal Medicine Clinic	Predictive regression algorithm to estimate risk of receiving simvastatin, clopidogrel, or warfarin	750
Vanderbilt University	Vanderbilt internal medicine and cardiology clinics	Predictive regression algorithm to estimate risk of receiving simvastatin, clopidogrel, or warfarin	1000