Table 5. Associations between Epicardial Adipose Tissue Volume and Extent of Plaque among those with any Plaque Present (Plaque score > 0).
Coronary Artery Calcium N= 93 |
Non-Calcified Plaque Score N= 423 |
Calcified Plaque Score N= 259 |
Mixed Plaque Score N= 239 |
Total Plaque Score N= 545 |
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Effect estimate (SE) | p-value | Effect estimate (SE) | p-value | Effect estimate (SE) | p-value | Effect estimate (SE) | p-value | Effect estimate (SE) | p-value | |
Model 1 | 0.048(0.013) | <0.001 | 0.011(0.006) | 0.06 | 0.010(0.009) | 0.26 | 0.005(0.009) | 0.54 | 0.021(0.007) | 0.001 |
Model 2 | 0.038(0.014) | 0.006 | 0.005(0.006) | 0.46 | 0.004(0.01) | 0.67 | 0.001(0.009) | 0.95 | 0.008(0.007) | 0.23 |
Model 3 | 0.042(0.015) | 0.005 | 0.007(0.007) | 0.31 | 0.004(0.01) | 0.73 | -0.005(0.01) | 0.66 | 0.010(0.008) | 0.17 |
Model 4 | 0.048(0.017) | 0.004 | 0.004(0.008) | 0.56 | 0.007(0.011) | 0.53 | -0.007(0.011) | 0.53 | 0.008(0.008) | 0.31 |
Linear Regression of natural log transformed plaque scores among those with any plaque present; estimate represents log-plaque score change per 10 units increase in epicardial adipose tissue volume. SE= standard error; Model 1- Adjusted for age, race and HIV serostatus; Model 2- Model 1 plus CAD risk factors; Model 3- Model 2 plus body mass index; Model 4- Model 2 plus abdominal visceral adipose volume. CAD risk factors include systolic blood pressure, antihypertensive medication use, diabetes mellitus, fasting glucose, fasting triglyceride, use of lipid-lowering medications, and smoking (pack-years).