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βHB-mediated HDAC inhibition plays a role in lifespan extension. (A) Survival of N2 worms in the presence of βHB, butyrate, or both compounds together. (B) Effects of hda-1, (C) hda-2, or (D) hda-3 RNAi knockdown on C. elegans lifespan in the presence or absence of 20 mM βHB.
