Table 1. Glutathione supplementation increases the tolerance of SIN3 KD flies to paraquat.
| Genotype | Sex | Relative Survival +Glutathione/-Glutathione | |||||
|---|---|---|---|---|---|---|---|
| 24 | 48 | 72 | |||||
| Control | KD | Control | KD | Control | KD | ||
| SIN3 I | ♂ | 0.95 | 1.5 | 1.69 | 4.67 | 2.3 | * |
| ♀ | 1.03 | 1.27 | 1.31 | 3.62 | 1.37 | 16.33 | |
| GFP | ♂ | 1.34 | 1.28 | 1.74 | 1.86 | 2.37 | 1.88 |
| ♀ | 1.27 | 1.28 | 1.33 | 1.4 | 1.92 | 1.53 | |
Control, flies without RU486; KD, flies with RU486; 24, 48, 72 = time in hr.
*
All flies without glutathione supplementation were dead. Ratios for each time point were calculated by dividing the number of flies surviving with glutathione supplementation by the number of flies surviving with no glutathione supplementation.