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. 2014 Aug 26;111(37):13319–13324. doi: 10.1073/pnas.1321940111

Fig. 6.

Fig. 6.

Assessment of viability of A549 cells treated with Cre− procapsids and of the cytotoxicity induced by the treatment of Cre− T4 NPs. (A) The cell uptake of unlabeled Cre− or Alexa 647-labeled Cre− (A647-T4) procapsids showed no cytotoxicity for A549 cells, which appeared 100% viable. (B–D) There is no apparent cytotoxicity in A549 cells treated with Cre− T4 procapsids (B) relative to the untreated cells (C), whereas most of the cells appeared dead (i.e., as rounded opaque spots) after treatment with Cre+ T4 procapsids (D). All bright-field images of A549 cells were obtained using a 20× objective. (Scale bars, 50 µm.)