Fig. 5.

Structural conservation between DpNCT and HsNCT. (A) Comparison of conserved structural features in DpNCT and HsNCT. Invariant residues among all five organisms (Fig. S2) are highlighted in red; conserved amino acids are colored yellow. (B) The bottom surface of the small lobe, which is in contact with the TMs of γ-secretase, is highly conserved. The small globular domain from the small lobe, which is in contact with the thin end of the TMs, is particularly conserved. The TMs of γ-secretase are shown in surface representation.