Fig. 7.

Spectinomycin binds primarily to hinge 2. Stereoview showing contacts between spectinomycin (Spc) (red) and 16S rRNA in the Escherichia coli 70S ribosome (25). The main contacts made by Spc are in the minor groove between h34 and h35 (grey), at the articulation point of hinge 2, where it forms hydrogen bonds with bases G1064, C1066, G1068, A1191, C1192, and G1193. Spc also contacts h28 (yellow) at the backbone between G1387 and C1388, away from the articulation point of hinge 1 at the bulged G926.