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. Author manuscript; available in PMC: 2014 Oct 1.
Published in final edited form as: J Immunol. 2014 Aug 27;193(7):3704–3716. doi: 10.4049/jimmunol.1401018

FIGURE 7. Proposed model for the local induction of APC-like neutrophils under the influence of microbe-responsive unconventional T-cells.

FIGURE 7

(A) Upon pathogen clearance, neutrophils release microbial metabolites into the microenvironment where they stimulate local or freshly recruited unconventional T-cells to release pro-inflammatory cytokines. (B) In the presence of unconventional T-cell derived mediators like GM-CSF, IFN-γ and TNF-α, bystander neutrophils acquire the capacity to act as APCs for tissue resident and/or newly arriving effector and memory CD4+ and CD8+ T-cells. Activated neutrophils may also gain access to inflamed draining lymph nodes and prime T-cell responses in secondary lymphoid tissues (not depicted).