Table 2.
List of nanoparticle formulations in each leaf node of the M5P model tree.
| Leaf node | Name | Description |
|---|---|---|
| LM1 | ASP7-130 | 2/0/20 PFOB (reprep RWF8-162) |
| RWF8-171 | 2/0/20 PFOB, 2mol% Phosphatidylserine | |
| GH12-49 | 2/0/20 PFOB control fibrinopeptide Rhodamine | |
| ASP8-142 | Liposome, No PEG | |
| ASP8-144 | Liposome, 5mol% PEG350 PE | |
| ASP8-146 | Liposome, 5mol% PEG3000 PE | |
| LM2 | RWF8-153 | 2/0/20 PFOB, 10mol% Sulfatide Lipid, NO DOTAP |
| LM3 | RWF8-159 | 2/0/20 PFOB, 10mol% Ganglioside Lipid, NO DOTAP |
| RWF8-179 | 2/0/20 PFOB, 5mol% PEG3000 PE, NO DOTAP | |
| RWF8-180 | 2/0/20 PFOB, 5mol% PEG3000 PE, 2mol% DOTAP | |
| LM4 | RWF8-162 | 2/0/20 PFOB, NO Ganglioside Lipid, NO DOTAP (Negative Control) |
| ASP8-30 | 2/0/20 PFOB | |
| ASP6-38 | 2/0/20 PFOB, 2mol% DOTAP, NO PEG | |
| ASP6-36 | 2/0/20 PFOB, 2mol% DOTAP, 5mol% PEG350 PE | |
| RWF9-48 | 2/0/20 PFOB, 2mol% 16:0 EPC | |
| RWF9-49 | 2/0/20 PFOB, 10mol% 16:0 EPC | |
| ASP6-46 | 2/0/20 PFOB, 2mol% Glutamate-Cholesterol, NO PEG | |
| ASP6-44 | 2/0/20 PFOB, 2mol% Glutamate-Cholesterol, 5mol% PEG350 PE | |
| ASP6-54 | 2/0/20 PFOB, 2mol% Glutamate-Cholesterol-DOTA, NO PEG | |
| ASP6-52 | 2/0/20 PFOB, 2mol% Glutamate-Cholesterol-DOTA, 5mol% PEG350 PE | |
| ASP6-132 | 2/0/20 PFOB, 2mol% Gd-DOTA-PEG-Cholesterol, NO PEG PE | |
| ASP6-130 | 2/0/20 PFOB, 2mol% Gd-DOTA-PEG-Cholesterol, 5mol% PEG350 PE | |
| bkim98 | polymeric BRIJ72/PS-b-PAA (13mg/ml) | |
| GH11-105 | 2/0/20 PFOB icam1-c11 peptide | |
| GH11-103 | 2/0/20 PFOB icam1-c16 peptide | |
| LM5 | ASP7-002 | 2/0/20 PFOB, 20mol% Gd DOTA PE |
| LM6 | RWF8-172 | 2/0/20 PFOB, 20mol% Phosphatidylserine |
| ASP6-50 | 2/0/20 PFOB, 20mol% Glutamate-Cholesterol, NO PEG | |
| ASP6-48 | 2/0/20 PFOB, 20mol% Glutamate-Cholesterol, 5mol% PEG350 PE | |
| ASP8-26 | 2/0/20 PFOB, 20mol% dipalmitoylphosphatidylserine | |
| ASP6-134 | 2/0/20 PFOB, 20mol% Gd-DOTA-PEG-Cholesterol, 5mol% PEG350 PE | |
| LM7 | RWF9-50 | 2/0/20 PFOB, 20mol% 16:0 EPC |
| ASP6-40 | 2/0/20 PFOB, 20mol% DOTAP, 5mol% PEG350 PE | |
| ASP8-22 | 2/0/20 PFOB, 20mol% DOTAP | |
| RWF8-154 | 2/0/20 PFOB, 10mol% Sulfatide Lipid, 20mol% DOTAP | |
| RWF8-181 | 2/0/20 PFOB, 5mol% PEG3000 PE, 20mol% DOTAP | |
| ASP6-136 | 2/0/20 PFOB, 20mol% Gd-DOTA-PEG-Cholesterol, NO PEG PE | |
| RWF8-160 | 2/0/20 PFOB, 10mol% Ganglioside Lipid, 20mol% DOTAP | |
| LM8 | ASP6-42 | 2/0/20 PFOB, 20mol% DOTAP, NO PEG |
| LM9 | RWF8-173 | 2/0/20 PFOB, 50mol% Phosphatidylserine |
| ASP8-16 | 2/0/20 PFOB, 50mol% DOTAP, 5mol% PEG350 PE | |
| ASP8-28 | 2/0/20 PFOB, 50mol% dipalmitoylphosphatidylserine | |
| RWF8-167 | 2/0/20 PFOB, 10mol% Ganglioside Lipid, 50mol% Glutamate-Cholesterol | |
| ASP8-46 | 2/0/20 PFOB, 50mol% EPC, No PEG | |
| ASP8-48 | 2/0/20 PFOB, 50mol% EPC, 5mol% PEG350 PE | |
| LM10 | ASP8-52 | 2/0/20 PFOB, 50mol% Phosphatidic Acid |
| ASP6-126 | 2/0/20 PFOB, 50mol% Glutamate-Cholesterol, 5mol% PEG350 PE | |
| ASP7-012 | 2/0/20 PFOB, 1mol% carboxy-PEG-DSPE, 30mol% Gd-DTPA-BOA | |
| LM11 | ELK5-183 | 2/0/20 PFOB, 30mol% Gd DOTA PE |
| LM12 | RWF9-51 | 2/0/20 PFOB, 50mol% 16:0 EPC |
| ASP8-50 | 2/0/20 PFOB, 50mol% EPC, 5mol% PEG3000 PE | |
| RWF8-155 | 2/0/20 PFOB, 10mol% Sulfatide Lipid, 50mol% DOTAP | |
| ASP6-90 | 2/0/20 PFOB, 50mol% DOTAP, 5mol% PEG350 PE | |
| ASP8-18 | 2/0/20 PFOB, 50mol% DOTAP, 5mol% PEG3000 PE | |
| LM13 | RWF8-161 | 2/0/20 PFOB, 10mol% Ganglioside Lipid, 50mol% DOTAP |
| ASP6-128 | 2/0/20 PFOB, 50mol% Glutamate-Cholesterol, NO PEG | |
| RWF8-182 | 2/0/20 PFOB, 5mol% PEG3000 PE, 50mol% DOTAP | |
| LM14 | ASP8-14 | 2/0/20 PFOB, 50mol% DOTAP, No PEG |
| RWF9-47 | 2/0/20 PFOB, 50mol% DOTAP, NO PEG (RePrep of ASP6-92) | |
| ASP8-24 | 2/0/20 PFOB, 50mol% DOTAP |