Bleeding and vascular complication definitions used for exploratory analyses

Modified TIMI	Modified ACUITY	CathPCI Registry	EASY Hematoma Scale
Major bleeding (any of the following): - Hemoglobin drop >5 g/dL with identified non–CABG-related bleeding site - Intracranial hemorrhage - Cardiac tamponade	Any of the following: - Intracranial bleeding - Retroperitoneal bleeding - Intraocular bleeding	Bleeding (any of the following): - Hemoglobin drop ≥3 g/dL - Transfusion of whole blood or packed red blood cells - Procedural intervention or surgery at bleeding site to reverse/stop or correct the bleeding (eg, surgical closures/exploration of arteriotomy site, balloon angioplasty to seal an arterial tear, endoscopy with cautery of a GI bleed)	Type I: ≤5 cm diameter - Type II: >5 cm but ≤10 cm diameter - Type III: >10 cm but not above the elbow - Type IV: extending above the elbow
Minor bleeding (any of the following): - Hemoglobin drop >3 g/dL but ≤5 g/dL with identified non–CABG-related bleeding site - Spontaneous gross hematuria	- Access site hemorrhage requiring surgical intervention - >5 cm diameter hematoma at puncture site - Reduction in hemoglobin concentration >4 g/dL without overt source of bleeding - Reduction in hemoglobin concentration >3 g/dL with overt source of bleeding - Reoperation for bleeding - Use of blood product transfusion	Vascular complication (including but not limited to the following): - Access site occlusion - Peripheral embolization - Arterial dissection - Pseudoaneurysm - Arteriovenous fistula	- Type V: anywhere with ischemic threat of the handM