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. Author manuscript; available in PMC: 2015 Oct 1.
Published in final edited form as: J Immunol. 2014 Aug 25;193(7):3409–3416. doi: 10.4049/jimmunol.1401194

Figure 6. Efficient deletion after constant exposure to cross-presented antigen is dependent upon bim expression, and the dose and TCR affinity of antigen.

Figure 6

B10.D2 mice containing donor WT or Bim-/- Thy1.1+ CL4 CD8+ T cells were treated on days 0, 3 and 6 with apoptotic cells carrying various concentrations of ILA-Native HA (a) or ILA-A517G (b) peptide. On day 30 mice were challenge with PR8 influenza virus (i.p. 500 HA units). Six days later, donor CL4 cells were detected by FACS in the spleen. Each graph is representative of 2 experiments using age and sex matched mice.