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. Author manuscript; available in PMC: 2015 Oct 1.
Published in final edited form as: Gastroenterology. 2014 Jun 21;147(4):835–846. doi: 10.1053/j.gastro.2014.06.024

Figure 3. MTF-1 regulates NOD2-induced MT expression and bacterial killing.

Figure 3

(A) MDMs were treated with MDP as in Fig.1. Fold MTF-1 mRNA induction. (B-F) MDMs were transfected with MTF-1 siRNA for 24h and then treated with 100 μg/ml MDP for 48h. (B) MTF-1 mRNA expression. (C) Representative western blot for MTF-1 expression. (D) mRNA expression of MT isoforms. (E) Representative western blot using an antibody recognizing both MT-1 and MT-2 isoforms. (F) Clearance of intracellular S. typhimurium, S. aureus or AIEC. Mean + SEM for n=4 (A-C) or n=8 (D-F). Pretx, pre-treatment; Tx, treatment; scr, scrambled; *, p<0.05; **, p<0.01;***, p<0.001.