Skip to main content
. Author manuscript; available in PMC: 2015 Oct 1.
Published in final edited form as: Gastroenterology. 2014 Jul 16;147(4):870–881.e8. doi: 10.1053/j.gastro.2014.07.005

Figure 7. Sequence variation in targeted epitope and reduced recognition by CD8 T cells in SR/CI patients.

Figure 7

(A) Sequences of the epitopes targeted by tetramer+ CD8 T cells in SR/CI patients at early and late time points during reinfection. (B) Responses of total PBMCs collected during reinfection in a dose-response IFN-γ ELISPOT assay to the reference sequences versus variant autologous sequences for two SR/SR patients in response to the NS3-1073 epitope (left panels), two SR/CI patients in response to the NS3-1073 epitope (middle panels) and two SR/CI patients in response to the NS3-1436 epitope (right panels).