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. Author manuscript; available in PMC: 2015 Sep 1.
Published in final edited form as: Mol Cell Neurosci. 2014 Jul 11;0:68–78. doi: 10.1016/j.mcn.2014.06.012

Fig. 7. Inverse dynamics of MBP expression and intracellular h-aSyn levels.

Fig. 7

(A) Intracellular levels of h-aSyn (normalized to h-aSyn signal at day 2 of differentiation) and fold change of MBP expression (compared to control conditions, i.e. to CTRL transduced cultures or without rh-aSyn exposure, respectively) are blotted. MBP expression increases in parallel with declining levels of intracellular h-aSyn using both approaches. (B) Proposed model for the effect of intracellular h-aSyn on the differentiation potential of OPCs. In presence of high h-aSyn levels, maturation towards high MBP-expressing pre-myelinating oligodendrocytes is impaired. After the intracellular h-aSyn level declines, the maturation potential is restored.