Table 2.
In vivo models of interest.
| References | Model | Scaffold | Construct type | Relevant details |
|---|---|---|---|---|
| Corona et al., 2014 | Heterologous MDCs | BAM | TA VML; Lewis rats | Uniaxial mechanical strain |
| Juhas et al., 2014 | GCaMP3+ Sprague-Dawley muscle tissue | Fibrin/Matrigel | In vitro model; dorsal skinfold window chamber in nude mice | Self contraction; in vitro maturation; in vivo vascularization; in vivo CTX damage regeneration |
| Carosio et al., 2013 | Autologous muscle tissue | Autologous ECM | EDL VML; C57BL6 WT, MLC/hAP | Self assembly, self contraction; response to electrical stimuli; vascularization |
| Corona et al., 2013a | Autologous muscle tissue | Autologous ECM | TA VML; Lewis rats | In vivo filler |
| Criswell et al., 2013 | GFP-FVB MPCs; HUVECs; 10T1/2 cells | Matrigel | Subcutaneous insertion in nude mice | In vivo activity of ECs and pericytes on SMTE constructs |
| Haraguchi et al., 2012 | Rat cadiac cells; HUVECs; HSMMCs | PNIPAAm substrate; fibrin, gelatin substrate; self produced ECM | Subcutaneous dorsal insertion, transplantation onto infarcted heart in F344 nude mice | Cell sheet stacking; electrical stimuli maturation; in vitro vascularization |
| Williams et al., 2012 | Explanted soleus muscle cells | Autologous ECM on fibrin | Implantation along the VL, near the sciatic nerve. Innervation with sural nerve in F344 | Self contraction and effect of innervation with host's nerve; shift in myosin type |
| Koffler et al., 2011 | C2C12; HUVECs; human foreskin fibroblasts | Surgisis SIS | Full thickness abdominal wall replacement in nude mice | Cocolture; variable in vitro conditioning period |
| Levenberg et al., 2005 | C2C12; HUVECs; mouse EFs | PLLA-PGA porous scaffold | Dorsal midline subcutaneous implantation in CB17 SCID | Coculture; prevascularization |
| Sicari et al., 2014 | – | SIS | ATC (3), quadriceps (2) VML | Clinical trial |
| Mase et al., 2010 | – | BAM | Quadriceps femori VML | Clinical case |
BAM, Bladder Acellular Matrix; CTX, CardioToXin; EDL, Extensor Digitorum Longus; EF, Embryonic Fibroblasts; HSMMC, Human Skeletal Muscle Myoblast Cells; HUVEC, Human Umbilical Vascular Endothelial Cell; MPC, Muscle Progenitor cell; PGA, PolyGlicolic Acid; PLLA, Poly-L-Lactic Acid; PNIPAAM, poly-N-IsoPropylAcrylAmide; SIS, Small Intestine Submucosa; TA, Tibialis Anterior.