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. 2014 Sep 22;5:499. doi: 10.3389/fmicb.2014.00499

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Copyright © 2014 Thoma, Sepulveda, Latus and Muth.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Association of spdA homologs with a conserved palindromic DNA sequence motif on Streptomyces plasmids. Alignment (CLUSTALW) of predicted SpdA proteins encoded by different Streptomyces plasmids (A). Conserved residues are indicated by shading (black >90%, gray >70% identity). Gaps were manually introduced to improve the alignment. The SRDD/E aa motif corresponding to sps is underlined. Multiple-sequence alignment of spdA palindromic (arrows) DNA sequence (sps) motifs associated with spdA genes (B). Conserved residues are indicated by gray boxes. ± Indicates position from the first base of the start codon. On pSVH1, the second palindrome overlaps with the translational start codon (underlined) of spdA.