Table 3.
Effect of lemon grass volatile oil on carrageenan-induced paw edema in mice
| LHP thickness (mm) (mean±SD) (% inhibition) | ||||
|---|---|---|---|---|
| Treatment | Dose (mg/kg) | 30 min | 90 min | 240 min |
| Control | 3.41±0.29a | 2.916±0.03a | 3.25±0.18a | |
| Diclofenac (mg/kg, orally) | 50 | 3.1±0.19b (86.20) | 2.916±0.03a (69.23) | 2.96±0.04b (88.88) |
| 10 | 2.88±0.09b,c (66.66) | 2.66±0.10b (82.75) | 2.75±0.13b,c (96.82) | |
| LGEO (mg/kg, by oral route) | 40 | 2.76±0.13b,c (95.56) | 2.68±0.16b (87.17) | 2.7±0.14b,c (95.20) |
| 100 | 2.88±0.07b,c (69.23) | 2.68±0.14b (86.20) | 2.75±0.10b,c (92.56) | |
| 200 | 2.88±0.098c (89.65) | 2.68±0.11b {69.23) | 2.73±0.12c (90.12) | |
Data are presented as mean (mm)±standard deviation (SD) (n=6/group). Groups of mice were pre-treated with vehicle (control group, oral administration, n=6), diclofenac (50 mg/kg, oral administration) or lemon grass essential oil (LGEO) at doses of 10, 40, 100, and 200 mg/kg (oral administration, n=6/group) 30 min before carrageenan-induced paw edema. LHP: left hind paw; LGEO: lemon grass essential oil. Means within the same column followed by the different letter are significantly different (P<0.05) according to ANOVA one-way analysis followed by Tukey's post hoc multiple comparison test.