Figure 2.

A: Linear association between adipocyte size at baseline and the change in GIR with overfeeding with low-dose insulin infusion (10 mU/min/m²), expressed as milligrams per minute · (estimated metabolic body size [EMBS]) (EMBS = FFM + 17.7). The association remained significant after using Pearson correlation (r = 0.42; P = 0.03) but was attenuated after removing the subject with the largest adipocytes (r = 0.36; P = 0.06). B: The three-dimensional relationship between baseline adipocyte size and change in GIR across baseline levels of FM illustrates that smaller adipocytes are associated with larger decreases in GIR for any given value of FM.