Table 2.
HRs for worsening ACR and eGFR with SBP and DBP categories relative to each reference BP category and A1C used in the multivariate analyses
| ACR | eGFR | |||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P | HR | 95% CI | P | |
| BP, mmHg | ||||||
| DBP 70–79 | Reference | Reference | ||||
| DBP <70 | 1.08 | 0.74–1.57 | 0.687 | 1.01 | 0.80–1.26 | 0.959 |
| DBP ≥80 | 1.03 | 0.69–1.55 | 0.887 | 0.96 | 0.73–1.26 | 0.763 |
| SBP 105–129 | Reference | Reference | ||||
| SBP <105 | 0.59 | 0.23–1.47 | 0.257 | 1.22 | 0.83–1.81 | 0.315 |
| SBP 130–139 | 1.88 | 1.28–2.77 | 0.001 | 1.08 | 0.84–1.38 | 0.566 |
| SBP ≥140 | 2.52 | 1.66–3.78 | <0.0001 | 0.42 | 0.13–1.31 | 0.135 |
| A1C | 1.19 | 1.09–1.31 | 0.0002 | 0.91 | 0.85–0.98 | 0.017 |
| A1C X† ≥140 mmHg | — | — | — | 1.15 | 1.00–1.32 | 0.045 |
| A1C baseline | 1.06 | 0.96–1.16 | 0.247 | 1.06 | 0.99–1.13 | 0.091 |
| SBP baseline | 1.00 | 0.99–1.01 | 0.792 | 1.01 | 1.00–1.02 | 0.008 |
| DBP baseline | 0.99 | 0.97–1.01 | 0.385 | 1.00 | 0.98–1.01 | 0.507 |
The total number of participants available for the final model of worsening ACR was 1,374, and for that of worsening eGFR, the number was 1,649. All variables are on study except baseline covariates.
†X represents the interaction between on-study A1C and the on-study SBP noted. Boldfaced text indicates data with statistically significant results.