Table 3.
HRs for worsening ACR and eGFR with PP categories relative to the reference category chosen from multivariate analyses that included baseline SBP, DBP, and A1C and on-study A1C among the covariates
| ACR |
eGFR |
|||||
|---|---|---|---|---|---|---|
| HR |
95% CI |
P |
HR |
95% CI |
P |
|
| PP, mmHg | ||||||
| 40–49 | Reference | Reference | ||||
| <40 | 0.36 | 0.15–0.87 | 0.022 | 1.02 | 0.71–1.45 | 0.934 |
| 50–59 | 1.11 | 0.71–1.72 | 0.651 | 1.00 | 0.76–1.30 | 0.986 |
| ≥60 | 2.38 | 1.58–3.59 | <0.0001 | 1.11 | 0.85–1.45 | 0.460 |
| A1C | 1.22 | 1.11–1.34 | <0.0001 | 0.95 | 0.89–1.01 | 0.105 |
| A1C baseline | 1.06 | 0.97–1.17 | 0.207 | 1.07 | 1.00–1.14 | 0.038 |
| SBP baseline, mmHg | 0.99 | 0.98–1.01 | 0.223 | 1.01 | 1.00–1.02 | 0.004 |
| DBP baseline, mmHg | 1.01 | 0.99–1.03 | 0.476 | 1.00 | 0.98–1.01 | 0.443 |
The total number of participants available for the final model of worsening ACR was 1,374, and for that of worsening eGFR, the number was 1,649. All variables are on study except baseline covariates. Boldfaced text indicates data with statistically significant results.