Table 5. Effects of infliximab therapy on conventional echocardiographic parameters versus prednisolone-treated patients.
Infliximab-treated RA patients (n = 20) | Prednisolone-treated RA patients (n = 18) | ||||||
Baseline | 3-month | p-value | Baseline | 3-month | p-value | p-value# | |
LV EDV (ml) | 81.7 ± 6.6 | 79.7 ± 6.9 | 0.411 | 83.9 ± 4.7 | 85.4 ± 9.8 | 0.868 | 0.2 |
LV ESV (ml) | 28.3 ± 4.2 | 27.2 ± 3.6 | 0.14 | 29.2 ± 5.3 | 27.9 ± 2.6 | 0.557 | 0.5 |
LV EF (ml) | 63.8 ± 4.0 | 64.6 ± 2.8 | 0.096 | 64.1 ± 3.3 | 64.9 ± 2.8 | 0.35 | 0.71 |
IVS (mm) | 9.7 ± 1.7 | 9.5 ± 3.9 | 0.267 | 9.5 ± 2.5 | 9.4 ± 4.6 | 0.316 | 0.06 |
PW (mm) | 8.6 ± 0.6 | 8.3 ± 0.4 | 0.056 | 8.5 ± 0.8 | 8.7 ± 0.4 | 0.381 | 0.82 |
S′ (cm/sec) | 7.2 ± 1.8 | 6.8 ± 0.8 | 0.258 | 7.4 ± 2.5 | 7.6 ± 0.6 | 0.369 | 0.1 |
E′ (cm/sec) | 7.9 ± 2.5 | 9.0 ± 1.3 | 0.181 | 8.3 ± 1.9 | 7.8 ± 2.4 | 0.6 | 0.09 |
E/E′ | 9.4 ± 3.9 | 8.0 ± 1.4 | < 0.01 | 8.5 ± 2.5 | 8.8 ± 2.4 | 0.379 | < 0.05 |
E (cm/s) | 76.1 ± 7.4 | 76.0 ± 11.8 | 0.979 | 77.9 ± 8.2 | 79.5 ± 11.7 | 0.493 | 0.476 |
A (cm/s) | 67.5 ± 9.9 | 66.0 ± 7.7 | 0.221 | 71.3 ± 11.2 | 70.2 ± 9.8 | 0.407 | 0.284 |
E/A | 1.1 ± 0.2 | 1.1 ± 0.2 | 0.758 | 1.1 ± 0.2 | 1.1 ± 0.3 | 0.184 | 0.656 |
DT (ms) | 199.1 ± 35.3 | 203.0 ± 34.1 | 0.609 | 198.6 ± 30.3 | 211.5 ± 22.4 | 0.055 | 0.858 |
IVRT (ms) | 96.7 ± 10.8 | 95.3 ± 16.9 | 0.626 | 90.3 ± 10.1 | 90.3 ± 16.8 | 0.99 | 0.056 |
Values are expressed as mean ± SD.
#For comparisons between infliximab- and prednisolone-treated patients at baseline.
LV = left ventricle, EDV = end-diastolic volume, ESV = end-systolic volume, EF = ejection fraction, IVS = interventricular septum, PW = posterior wall, DT = deceleration time, IVRT = isovolumic relaxation time.