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. Author manuscript; available in PMC: 2015 Sep 18.
Published in final edited form as: Mol Cell. 2014 Sep 11;55(6):904–915. doi: 10.1016/j.molcel.2014.08.010

Figure 5. MAFG and its Corepressors Mediate CIMP in BRAF-Positive RKO Cells.

Figure 5

(A and B) qRT-PCR analysis monitoring expression of CIMP genes in RKO cells expressing a MAFG or CHD8 shRNA (A) or a BACH1 or DNMT3B shRNA (B). The results were normalized to that obtained with the NS control, which was set to 1.

(C) Bisulfite sequencing analysis of representative CIMP genes in RKO cells expressing a NS, MAFG, CHD8, BACH1 or DNMT3B shRNA.

(D) ChIP analysis monitoring binding of MAFG, BACH1, CHD8 and DNMT3B on representative CIMP gene promoters in RKO cells. Data are represented as mean ± SD. *P≤0.05, **P≤0.01. See also Figure S5.