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. 2014 Jun 26;5(14):5547–5558. doi: 10.18632/oncotarget.2139

Figure 6. HGFL promotes survival of Ron expressing prostate cancer cells and induces STAT3 activation and Bcl2 expression under detached conditions.

Figure 6

A). Western blot depicting lentiviral transduction of a Ron cDNA into prostate cancer epithelial cells (TR9) derived from prostate tumors from TRAMP+ mice deficient for the Ron receptor. B). MTT assays demonstrate a survival advantage for TR9 Ron prostate cancer cells under serum-free conditions in presence of HGFL. Bar graph depicts the fold change in cell number compared to untreated cells and is representative of data from three independent experiments performed in duplicate. Data are expressed as the mean ± SE, *P<0.05. C). Western blot analysis of serum-starved TR9 and TR9 Ron cells in presence and absence of HGFL. A significant increase in pSTAT3 and Bcl2 levels was observed in TR9 Ron cells upon treatment with recombinant HGFL at day 6.