Table 1. Patients characteristics.

	Patient 1	Patient 2	Patient 3	Patient 4	Patient 5
Sex	Male	Male	Male	Female	Male
Age at diagnosis, years	23	57	59	54	63
EUTOS score	Low risk (42)	Low risk (49)	Low risk (54)	Low risk (14)	Low risk (14)
Initial ratio BCR-ABL/ABL (%)	50	45	52	62	50
Initial WBC (/nl)	112.3	28.4	394.8	55.9	43.1
BCR-ABL transcript type	b2a2	b3a2	b2a2	b3a2	b3a2
Therapy	nilotinib	nilotinib	nilotinib	nilotinib	ponatinib
3 month BCR-ABL (IS)	0.008	0.013	0.055	20.5	0.263
3 month WBC (/nl)	4.2	5.1	6.7 *	13.1 *	13.1
Response at 3 months	MMR	MMR	MMR *	MinCyR *	n.d.

MMR, major molecular response; MinCyR, minimal cytogenetic response; IS, international scale; WBC, white blood cells;

^*6 month; n.d., not detected after 3 months.