A. Promoter methylation frequency for the 8 genes analyzed in the primary LGPUCC samples (non-recurrent versus recurrent).
GENE | Methylation positive% (number of methylation positive/number of total cases) | Fisher's exact test p-value | |
---|---|---|---|
Non-recurrent tumors | Recurrent tumors | ||
CCND2 | 2/17 (11.7%) | 10/19 (52.6%) | 0.014* |
CCNA1 | 4/17 (23.5%) | 11/19 (57.9%) | 0.048* |
CALCA | 4/17 (23.5%) | 10/19 (52.6%) | 0.097 |
AIM1 | 8/17 (47%) | 14/19 (73.9%) | 0.171 |
NID2 | 3/17 (17.6%) | 13/19 (68.4%) | 0.003* |
ARF | 2/17 (11.7%) | 0/19 (0%) | 0.216 |
TIMP3 | 10/17 (58.8%) | 4/19 (21%) | 0.039* |
RARβ2 | 5/17 (29.4%) | 3/19 (15.8%) | 0.434 |
p values <0.05 were considered statistically significant