A. Promoter methylation frequency for the 8 genes analyzed in the primary LGPUCC samples (non-recurrent versus recurrent).

GENE	Methylation positive% (number of methylation positive/number of total cases)		Fisher's exact test p-value
	Non-recurrent tumors	Recurrent tumors
CCND2	2/17 (11.7%)	10/19 (52.6%)	0.014*
CCNA1	4/17 (23.5%)	11/19 (57.9%)	0.048*
CALCA	4/17 (23.5%)	10/19 (52.6%)	0.097
AIM1	8/17 (47%)	14/19 (73.9%)	0.171
NID2	3/17 (17.6%)	13/19 (68.4%)	0.003*
ARF	2/17 (11.7%)	0/19 (0%)	0.216
TIMP3	10/17 (58.8%)	4/19 (21%)	0.039*
RARβ2	5/17 (29.4%)	3/19 (15.8%)	0.434

^*p values <0.05 were considered statistically significant