Table 1.
FDCP-EpoR JAK2WT |
FDCP-EpoR JAK2V617F |
||||||
---|---|---|---|---|---|---|---|
0 | IC50 | IC80 | 0 | IC50 | IC80 | ||
A. Apoptosis (% Annexin V positive) | 48 h | 11 (±2) | 17 (±3) | 96 (±7) | 14 (±2) | 46 (±1) | 89 (±5) |
72 h | 18 (± 2) | 33 (±5) | 97 (±10) | 17 (±7) | 57 (±3) | 95 (±9) | |
B. Mitochondrial membrane potential (% CMX negative) | 48 h | 16 (±2) | 32 (±4) | 99 (±6) | 8 (±4) | 18 (±6) | 89 (±4) |
72 h | 15 (±4) | 44 (±4) | 99 (±4) | 14 (±6) | 23 (±8) | 99 (±7) |