Table 5. Results of logistic regression models for log-additive versus recessive associations between 15 CX3CR1 SNPs with age-related macular degeneration using pooled data from 5 study populations.
Additive Models | Recessive Models | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
| ||||||||||
Adjusted for age, sex, smoking, and obesity | Also adjusted for CFH, ARMS2, C3 | Adjusted for age, sex, smoking, and obesity | Also adjusted for CFH, ARMS2, C3 | |||||||
| ||||||||||
SNP | OR | P-value | OR | P-value | Permutation P-value | OR | P-value | OR | P-value | Permutation P-value |
rs3732378 | 0.92 | 0.24 | 0.87 | 0.074 | 0.062 | 0.92 | 0.7 | 0.92 | 0.72 | 0.75 |
rs3732379 | 1.02 | 0.80 | 1.01 | 0.85 | 0.86 | 1.09 | 0.54 | 1.09 | 0.58 | 0.59 |
rs2669845 | 1.15 | 0.069 | 1.14 | 0.12 | 0.14 | 1.38 | 0.28 | 1.28 | 0.43 | 0.61 |
rs2853712 | 1.00 | 0.97 | 1.00 | 0.96 | 0.99 | 1.01 | 0.91 | 0.99 | 0.93 | 0.91 |
rs11715522 | 1.08 | 0.18 | 1.11 | 0.073 | 0.084 | 1.26 | 0.027 | 1.27 | 0.034 | 0.038 |
rs2853711 | 0.99 | 0.89 | 0.96 | 0.52 | 0.42 | 1.14 | 0.33 | 1.12 | 0.43 | 0.52 |
rs1014638 | 1.02 | 0.67 | 1.02 | 0.77 | 0.79 | 1.15 | 0.30 | 1.09 | 0.58 | 0.54 |
rs13062158 | 1.01 | 0.80 | 1.05 | 0.46 | 0.52 | 1.23 | 0.13 | 1.18 | 0.27 | 0.25 |
rs2853707 | 0.91 | 0.15 | 0.88 | 0.069 | 0.066 | 0.89 | 0.50 | 0.83 | 0.31 | 0.27 |
rs9862876 | 1.00 | 0.94 | 0.99 | 0.82 | 0.84 | 1.04 | 0.80 | 1.08 | 0.64 | 0.55 |
rs12636547 | 0.87 | 0.12 | 0.85 | 0.098 | 0.10 | 0.62 | 0.28 | 0.60 | 0.32 | 0.20 |
rs17793056 | 0.94 | 0.25 | 0.93 | 0.21 | 0.19 | 0.98 | 0.83 | 0.93 | 0.43 | 0.41 |
rs17038640 | 1.04 | 0.45 | 1.07 | 0.25 | 0.21 | 1.13 | 0.29 | 1.14 | 0.31 | 0.28 |
rs9868689 | 0.97 | 0.62 | 0.97 | 0.68 | 0.71 | 0.95 | 0.77 | 1.00 | 0.98 | 0.95 |
rs1877563 | 0.85 | 0.056 | 0.84 | 0.056 | 0.060 | 0.80 | 0.56 | 0.89 | 0.76 | 0.79 |