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. Author manuscript; available in PMC: 2014 Sep 22.

Published in final edited form as: Phys Med Biol. 2013 Sep 4;58(18):6541–6563. doi: 10.1088/0031-9155/58/18/6541

Comparison of experimentally measured loss of echogenicity with the numerically calculated loss of echogenicity from (a) ELIP and (b) Definity^®. Flowing ELIP or Definity^® were exposed to a Doppler pulse of duration 1.66 μs. The numerically calculated loss of echogenicity was based on ELIP or Definity^® rupture ( ), subharmonic (SH) emissions from ELIP or Definity^® ( ), (SH) emissions from bubbles without a stabilizing shell ( ), or inertial collapse of bubbles without a stabilizing shell ( ).

Comparison of experimentally measured loss of echogenicity with the numerically calculated loss of echogenicity from (a) ELIP and (b) Definity^®. Flowing ELIP or Definity^® were exposed to a Doppler pulse of duration 1.66 μs. The numerically calculated loss of echogenicity was based on ELIP or Definity^® rupture ( ), subharmonic (SH) emissions from ELIP or Definity^® ( ), (SH) emissions from bubbles without a stabilizing shell ( ), or inertial collapse of bubbles without a stabilizing shell ( ).