. Author manuscript; available in PMC: 2015 Sep 1.

Published in final edited form as: Bioorg Med Chem Lett. 2014 Jul 15;24(17):4308–4311. doi: 10.1016/j.bmcl.2014.07.013

Table 2.

Data for analogues with a sulfonamide substituent at the 3-position of the phenyl ring.

Cmpd.	PHOSPHO1^a	PMI^b IC₅₀ [μM]	PMM2^b
2s	0.50	2.8	13
2t	0.56	> 50	> 100
2u	0.81	0.71	5.2
2v	1.2	2.6	9.9
2w	1.8	3.1	11
2x	1.1	8.6	63
2y	7.5	7.5	30

See Dahl et al., 2011^8a for assay protocol.