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Inhibitory effects of adding ribavirin (RBV) at different stages of the replication cycle of canine distemper virus (CDV). The concentrations of RBV (12.2 and 24.4 μg/mL) were added at the times corresponding to the stages of pre-treatment (−1 h), adsorption (0 h), penetration (1 h), and intracellular (2 h).
** Concentrations statistically different compared to control (P < 0.01) and inhibitory activity ≥ 1 log10.
