Figure 3.

Inhibitory effects of adding the combination ribavirin + interferon-alpha (RBV + IFNα) at different stages of the replication cycle of canine distemper virus (CDV). The concentrations of the RBV + IFNα (12.2 + 0.03 μg/mL and 12.2 + 0.06 μg/mL) were added at the times corresponding to the stages of pre-treatment (−1 h), adsorption (0 h), penetration (1 h), and intracellular (2 h).

** Concentrations statistically different compared to control (P < 0.01) and inhibitory activity ≥ 1 log₁₀.