Table I.
Cytotoxicity, anti-CDV activity, and selectivity indexes of the compounds tested
| Compounds | Ciytotoxicity CC50a (μg/mL) | Antiviral activity IC50a (μg/mL) | Selectivity index (SI)b |
|---|---|---|---|
| RBV | 353 ± 48 | 8.32 ± 0.004 | 42.4 |
| IFNα | 0.36 ± 0.06 | 0.024 ± 0.001 | 15 |
| DMSO (%) | 2.11 ± 0.11 | — | — |
a
CC50 (50% inhibitory concentration) and IC50 (50% cytotoxic concentration) values represent mean ± standard error of the mean values. Experiments were done in triplicate.
b
Selectivity index (CC50/IC50).
CDV — canine distemper disorder; RBV — ribavirin; IFNα — interferon-alpha; DMSO — dimethyl sulfoxide.