. 2014 Oct;78(4):283–289.

Table II.

Relationship between viral titers corresponding to the positive controls and treatments with RBV (12.2 μg/mL), IFNα (C1 0.03 μg/mL and C2 0.06 μg/mL), and RBV + IFNα (C1 12.2 μg/mL + 0.03 μg/mL and C2 12.2 μg/mL + 0.06 μg/mL) for CDV stages of replication

	Log viral titer C+/Log viral titer [C]

	−1 h		0 h		1 h		2 h

Treatments	C1	C2	C1	C2	C1	C2	C1	C2
RBV¹	1.14^a	1.14^a	1.03^b	1.03^a	0.98^b	0.98^b	1.42^a	1.42^a
IFNα	1.06^a	1.02^a	1.19^a	1.08^a	1.11^b	1.15^b	1.17^b	1.29^a
RBV + IFNα	1.01^a	1.03^a	1.17^a	1.19^a	1.28^a	1.27^a	1.27^a,b	1.42^a
F value	3.57 NS	5.55 NS	8.46	4.34 NS	10.0^*	6.27^*	9.0^*	1.30 NS
CV (%)	6.21	4.65	4.60	6.34	7.21	8.95	5.62	8.48

Values in bold indicate a significant reduction in virus titer compared to the virus control (P < 0.05) and inhibitory activity ≥ 1 log₁₀.

Averages represented by the same lower-case letter (column) and upper-case letter (row) did not differ by Tukey test.

C+ — untreated infected cells (positive control); [C] — treated infected cells; −1 h — pre-treatment; 0 h — adsorption; 1 h — penetration; 2 h — intracellular; RBV — ribavirin; IFNα — interferon-alpha; NS — not significant.

Antiviral action is statistically significant by Tukey’s test, P < 0.05.

C1 = C2 = 12.2 μg/mL, single RBV concentration used in association with IFNα.

CV — coefficient of variance.