Comparison 17. Sensitivity analyses by allocation concealment, drug versus placebo or no intervention.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Mortality	44	5378	Risk Ratio (M‐H, Fixed, 95% CI)	0.65 [0.54, 0.78]
1.1 allocation A	15	3581	Risk Ratio (M‐H, Fixed, 95% CI)	0.71 [0.53, 0.97]
1.2 allocation B	29	1797	Risk Ratio (M‐H, Fixed, 95% CI)	0.62 [0.49, 0.77]
2 Febrile patients	51	6317	Risk Ratio (M‐H, Random, 95% CI)	0.79 [0.73, 0.86]
2.1 allocation A	16	3844	Risk Ratio (M‐H, Random, 95% CI)	0.83 [0.73, 0.95]
2.2 allocation B	35	2473	Risk Ratio (M‐H, Random, 95% CI)	0.75 [0.66, 0.85]
3 Clinically documented infection	47	5660	Risk Ratio (M‐H, Random, 95% CI)	0.66 [0.57, 0.77]
3.1 allocation A	13	3408	Risk Ratio (M‐H, Random, 95% CI)	0.64 [0.50, 0.82]
3.2 allocation B	34	2252	Risk Ratio (M‐H, Random, 95% CI)	0.66 [0.55, 0.80]
4 Microbiologically documented infection	51	6100	Risk Ratio (M‐H, Random, 95% CI)	0.52 [0.43, 0.62]
4.1 allocation A	15	3727	Risk Ratio (M‐H, Random, 95% CI)	0.50 [0.36, 0.71]
4.2 allocation B	36	2373	Risk Ratio (M‐H, Random, 95% CI)	0.52 [0.42, 0.65]