Table 1.
Dysregulated components of Wnt signaling in the spinal cords of ALS mice compared to WT mice
| Symbol | Description | Fold difference
|
||
|---|---|---|---|---|
| 95 days | 108 days | 122 days | ||
| Wnt ligands | ||||
| Wnt1 | Wingless-related MMTV integration site 1 | 2.10 | −1.69 | 1.23 |
| Wnt10a | Wingless related MMTV integration site 10a | 1.79 | −1.52 | 2.08 |
| Wnt11 | Wingless-related MMTV integration site 11 | −1.06 | −1.76 | 2.07 |
| Wnt16 | Wingless-related MMTV integration site 16 | 1.80 | −3.42 | 2.39 |
| Wnt2 | Wingless-related MMTV integration site 2 | 1.37 | 1.74 | 8.38 |
| Wnt3 | Wingless-related MMTV integration site 3 | −1.64 | −1.78 | 5.40 |
| Wnt3a | Wingless-related MMTV integration site 3A | 7.47 | 1.40 | 1.01 |
| Wnt4 | Wingless-related MMTV integration site 4 | 1.64 | 2.59 | 5.76 |
| Wnt5a | Wingless-related MMTV integration site 5A | 1.41 | −1.10 | 15.65 |
| Wnt5b | Wingless-related MMTV integration site 5B | 1.12 | −1.47 | 3.65 |
| Wnt7a | Wingless-related MMTV integration site 7A | 1.99 | 1.79 | 2.11 |
| Wnt7b | Wingless-related MMTV integration site 7B | 3.91 | 1.44 | 6.10 |
| Wnt8a | Wingless-related MMTV integration site 8A | 2.78 | −1.55 | 1.23 |
| Wnt8b | Wingless related MMTV integration site 8b | −1.11 | −2.38 | −1.12 |
| Wnt9a | Wingless-type MMTV integration site 9A | 1.91 | −1.02 | 5.32 |
| Receptors | ||||
| Fzd1 | Frizzled homolog 1 (Drosophila) | 1.67 | 1.05 | 3.42 |
| Fzd2 | Frizzled homolog 2 (Drosophila) | −1.21 | 1.10 | 2.59 |
| Fzd3 | Frizzled homolog 3 (Drosophila) | 2.23 | −1.05 | 3.03 |
| Fzd4 | Frizzled homolog 4 (Drosophila) | 1.00 | −1.05 | 10.11 |
| Fzd5 | Frizzled homolog 5 (Drosophila) | −1.13 | −1.48 | 2.56 |
| Fzd6 | Frizzled homolog 6 (Drosophila) | 1.95 | 1.80 | 3.70 |
| Fzd7 | Frizzled homolog 7 (Drosophila) | 1.04 | −1.94 | 29.03 |
| Fzd8 | Frizzled homolog 8 (Drosophila) | 1.73 | 1.18 | 70.87 |
| Lrp5 | Low density lipoprotein receptor-related protein 5 | 1.34 | 1.80 | 5.76 |
| Downstream molecules | ||||
| Btrc | Beta-transducin repeat containing protein | −1.24 | −1.86 | 3.36 |
| Ccnd1 | Cyclin D1 | −1.17 | 1.37 | 7.71 |
| Ccnd2 | Cyclin D2 | −1.34 | −1.03 | 7.24 |
| Ccnd3 | Cyclin D3 | −1.28 | −1.34 | 2.41 |
| Csnk1a1 | Casein kinase 1, alpha 1 | 1.30 | −2.96 | 2.46 |
| Ctnnb1 | Catenin (cadherin associated protein), beta 1 | 1.30 | −1.25 | 2.18 |
| Dvl1 | Dishevelled, dsh homolog 1 (Drosophila) | 1.04 | −1.55 | 4.70 |
| Dvl2 | Dishevelled 2, dsh homolog (Drosophila) | −1.13 | −2.01 | 1.04 |
| Ep300 | E1A binding protein p300 | −1.32 | −1.45 | 2.04 |
| Fbxw11 | F-box and WD-40 domain protein 11 | −1.03 | −1.46 | 2.74 |
| Fbxw4 | F-box and WD-40 domain protein 4 | −1.24 | 1.03 | 4.69 |
| Fgf4 | Fibroblast growth factor 4 | −1.19 | 12.13 | 1.23 |
| Fosl1 | Fos-like antigen 1 | 4.06 | 3.34 | 17.00 |
| Frat1 | Frequently rearranged in advanced T-cell lymphomas | 3.64 | −3.72 | 1.13 |
| Frzb | Frizzled-related protein | 1.22 | −2.90 | 3.70 |
| Jun | Jun oncogene | 1.07 | −1.03 | 2.44 |
| Lef1 | Lymphoid enhancer binding factor 1 | 1.27 | −2.19 | −1.34 |
| Myc | Myelocytomatosis oncogene | −829.19 | 1.63 | 21.92 |
| Nkd1 | Naked cuticle 1 homolog (Drosophila) | 1.25 | −2.08 | 1.07 |
| Nlk | Nemo like kinase | −1.17 | −1.56 | 10.28 |
| Pitx2 | Paired-like homeodomain transcription factor 2 | −1.53 | −4.24 | 7.35 |
| Ppp2r5d | Protein phosphatase 2, regulatory subunit B (B56), delta isoform | 1.30 | −1.06 | 2.91 |
| Rhou | Ras homolog gene family, member U | 1.30 | −1.63 | 3.17 |
| Senp2 | SUMO/sentrin specific peptidase 2 | 1.07 | −1.04 | 4.68 |
| Sfrp1 | Secreted frizzled-related protein 1 | −1.03 | −3.97 | −1.27 |
| Sfrp4 | Secreted frizzled-related protein 4 | −1.66 | 5.13 | 2.03 |
| Slc9a3r1 | Solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 | −1.09 | 1.09 | 2.48 |
| Sox17 | SRY-box containing gene 17 | 1.78 | −1.23 | 6.74 |
| T | Brachyury | −2.25 | −3.66 | 25.27 |
| Tcf3 | Transcription factor 3 | 1.15 | −1.26 | 2.91 |
| Tcf7 | Transcription factor 7, T-cell specific | −5.36 | −1.35 | −298.38 |
| Tle1 | Transducin-like enhancer of split 1, homolog of Drosophila E(spl) | 2.27 | 1.01 | 1.63 |
| Tle2 | Transducin-like enhancer of split 2, homolog of Drosophila E(spl) | −1.48 | −2.17 | −1.34 |
| Wif1 | Wnt inhibitory factor 1 | −1.11 | 24.80 | 2.13 |
Positive fold difference indicated up-regulated while negative fold difference indicated down-regulated
Bold values indicate transcripts that showed an increase/decrease of at least twofold with statistical significance in ALS mice compared to WT mice