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. Author manuscript; available in PMC: 2015 Nov 1.
Published in final edited form as: Neurobiol Aging. 2014 May 27;35(11):2486–2494. doi: 10.1016/j.neurobiolaging.2014.05.019

Table 3.

Cross-sectional associations between CSF ceramides and sphingomyelins and CSF amyloid-beta and tau using multivariate linear regression

All individuals (n = 91)a Age <54 (n = 44) Age ≥54 (n = 47) No APOE E4 (n = 58) APOE E4 (n = 33)
Log sphingolipid b (SE) p value b (SE) p value b (SE) p value b (SE) p value b (SE) p value
Ceramide C 18:0 ABX-38b 302.75 (96.57) 0.002 163.11 (158.45) 0.309 418.91 (120.88) 0.001 286.68 (103.30) 0.008 358.88 (204.89) 0.090
ABX-40b 983.20 (291.75) 0.001 549.37 (474.95) 0.254 1349.24 (365.49) 0.001 868.16 (341.89) 0.014 1298.58 (549.95) 0.025
ABX-42b 67.24 (30.58) 0.031 21.21 (49.84) 0.522 90.07 (38.76) 0.025 66.01 (36.62) 0.077 69.02 (57.31) 0.238
AB1-42c 19.12 (10.44) 0.071 14.46 (14.37) 0.320 21.19 (15.10) 0.168 19.49 (11.88) 0.107 18.47 (21.07) 0.388
tauc 13.44 (3.49) <0.001 7.61 (5.41) 0.167 18.18 (4.63) <0.001 13.70 (4.03) 0.001 12.77 (6.91) 0.075
p-tau 181c 2.80 (2.84) 0.327 0.81 (4.77) 0.867 4.38 (3.55) 0.224 0.94 (2.92) 0.750 6.37 (6.24) 0.315
tau/AB1-42c 0.03 (0.01) 0.039 0.01 (0.01) 0.244 0.04 (0.02) 0.062 0.03 (0.01) 0.025 0.03 (0.03) 0.391
Total sphingomyelin ABX-38b 653.29 (128.14) <0.001 3.89 (202.17) 0.021 816.50 (158.79) <0.001 450.22 (149.83) 0.004 1152.83 (216.49) <0.001
ABX-40b 2037.57 (387.32) <0.001 1502.38 (605.20) 0.017 2553.43 (481.13) <0.001 1455.48 (492.0) 0.005 3490.53 (548.05) <0.001
ABX-42b 173.49 (41.01) <0.001 158.65 (62.64) 0.015 184.46 (53.72) 0.001 129.12 (52.42) 0.017 266.29 (66.48) <0.001
AB1-42c 47.00 (14.40) 0.002 45.39 (18.24) 0.017 45.43 (21.68) 0.042 35.79 (17.17) 0.042 71.80 (26.93) 0.012
tauc 24.56 (4.73) <0.001 18.69 (6.86) 0.009 30.68 (6.44) <0.001 18.22 (6.01) 0.004 37.74 (7.58) <0.001
p-tau181c 10.85 (3.92) 0.007 13.48 (6.06) 0.032 9.79 (5.11) 0.062 4.53 (4.24) 0.290 22.48 (7.91) 0.008
tau/AB1-42c 0.05 (0.02) 0.007 0.03 (0.01) 0.053 0.08 (0.03) 0.020 0.03 (0.02) 0.068 0.09 (0.04) 0.037

Key: CSF, cerebrospinal fluid. SE, standard error.

a

Models control for age and APOE E4 allele; Models stratified by age control for APOE E4 genotype.

b

Assays conducted using Meso Scale Discovery (MSD) electrochemiluminescence.

c

Assays conducted using INNO-BIO AlzBio3 (xMAP).