Table 3.
All individuals (n = 91)a | Age <54 (n = 44) | Age ≥54 (n = 47) | No APOE E4 (n = 58) | APOE E4 (n = 33) | |||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Log sphingolipid | b (SE) | p value | b (SE) | p value | b (SE) | p value | b (SE) | p value | b (SE) | p value | |
Ceramide C 18:0 | ABX-38b | 302.75 (96.57) | 0.002 | 163.11 (158.45) | 0.309 | 418.91 (120.88) | 0.001 | 286.68 (103.30) | 0.008 | 358.88 (204.89) | 0.090 |
ABX-40b | 983.20 (291.75) | 0.001 | 549.37 (474.95) | 0.254 | 1349.24 (365.49) | 0.001 | 868.16 (341.89) | 0.014 | 1298.58 (549.95) | 0.025 | |
ABX-42b | 67.24 (30.58) | 0.031 | 21.21 (49.84) | 0.522 | 90.07 (38.76) | 0.025 | 66.01 (36.62) | 0.077 | 69.02 (57.31) | 0.238 | |
AB1-42c | 19.12 (10.44) | 0.071 | 14.46 (14.37) | 0.320 | 21.19 (15.10) | 0.168 | 19.49 (11.88) | 0.107 | 18.47 (21.07) | 0.388 | |
tauc | 13.44 (3.49) | <0.001 | 7.61 (5.41) | 0.167 | 18.18 (4.63) | <0.001 | 13.70 (4.03) | 0.001 | 12.77 (6.91) | 0.075 | |
p-tau 181c | 2.80 (2.84) | 0.327 | 0.81 (4.77) | 0.867 | 4.38 (3.55) | 0.224 | 0.94 (2.92) | 0.750 | 6.37 (6.24) | 0.315 | |
tau/AB1-42c | 0.03 (0.01) | 0.039 | 0.01 (0.01) | 0.244 | 0.04 (0.02) | 0.062 | 0.03 (0.01) | 0.025 | 0.03 (0.03) | 0.391 | |
Total sphingomyelin | ABX-38b | 653.29 (128.14) | <0.001 | 3.89 (202.17) | 0.021 | 816.50 (158.79) | <0.001 | 450.22 (149.83) | 0.004 | 1152.83 (216.49) | <0.001 |
ABX-40b | 2037.57 (387.32) | <0.001 | 1502.38 (605.20) | 0.017 | 2553.43 (481.13) | <0.001 | 1455.48 (492.0) | 0.005 | 3490.53 (548.05) | <0.001 | |
ABX-42b | 173.49 (41.01) | <0.001 | 158.65 (62.64) | 0.015 | 184.46 (53.72) | 0.001 | 129.12 (52.42) | 0.017 | 266.29 (66.48) | <0.001 | |
AB1-42c | 47.00 (14.40) | 0.002 | 45.39 (18.24) | 0.017 | 45.43 (21.68) | 0.042 | 35.79 (17.17) | 0.042 | 71.80 (26.93) | 0.012 | |
tauc | 24.56 (4.73) | <0.001 | 18.69 (6.86) | 0.009 | 30.68 (6.44) | <0.001 | 18.22 (6.01) | 0.004 | 37.74 (7.58) | <0.001 | |
p-tau181c | 10.85 (3.92) | 0.007 | 13.48 (6.06) | 0.032 | 9.79 (5.11) | 0.062 | 4.53 (4.24) | 0.290 | 22.48 (7.91) | 0.008 | |
tau/AB1-42c | 0.05 (0.02) | 0.007 | 0.03 (0.01) | 0.053 | 0.08 (0.03) | 0.020 | 0.03 (0.02) | 0.068 | 0.09 (0.04) | 0.037 |
Key: CSF, cerebrospinal fluid. SE, standard error.
Models control for age and APOE E4 allele; Models stratified by age control for APOE E4 genotype.
Assays conducted using Meso Scale Discovery (MSD) electrochemiluminescence.
Assays conducted using INNO-BIO AlzBio3 (xMAP).