Table 2.
Top three most enriched biological processes of genes differentially expressed in human peripheral blood mononuclear cells when exposed to varying doses of 60Co radiation according to the gene ontology enrichment analysis.
| Dose | GO ID | Biological process | P value (BH) | Gene symbol |
|---|---|---|---|---|
| 0.5 | GO:0045935 | Positive regulation of nucleobase-containing compound metabolic process | 0.0012a | SS18, SMARC2, EPAS1, LHX1, ZNF148, KLF6, F2R |
| GO:0051254 | Positive regulation of RNA metabolic process | 0.0006a | TNSF10, MCL1 | |
| GO:2001236 | Regulation of extrinsic apoptotic signaling pathway | 0.0011a | TNSF10, MCL1 | |
|
| ||||
| 1 | GO:0002376 | Immune system process | 0.0018 | 109 genesb |
| GO:0006955 | Immune response | 0.0213 | 69 genesb | |
| GO:0012501 | Programmed cell death | 0.03 | 88 genesb | |
|
| ||||
| 2.5 | GO:0044092 | Negative regulation of molecular function | 0.0299 | NKX3-1, DUSP6, CDC27, PRDX3, CAST, PSMC2, BAX, AZIN1, PSMA1, PELI1, CD44, HIPK3, SERPINB2, PI3, SENP2, RLIM, THBS1 |
| GO:0019221 | Cytokine-mediated signaling pathway | 0.0299 | IL1R1, RANBP2, CCL2, NUP54, CD44, IL1A, IFNGR1, KLF6, EIF4G2, JAK3, CXCR3, HLA-DRB5 | |
| GO:0071345 | Cellular response to cytokine stimulus | 0.0299 | RANBP2, IL1R1, RANBP2, CCL2, NUP54, CD44, IL1A, IFNGR1, KLF6, EIF4G2, JAK3, CXCR3, HLA-DRB5 | |
|
| ||||
| 5 | GO:0071310 | Cellular response to organic substance | 0.009 | 34 genesb |
| GO:0019221 | Cytokine-mediated signaling pathway | 0.0034 | USP18, NUP54, IFNAR1, IL1A, CXCR3, EIF4G2, NUP98, TRADD, SOCS3, NUMBL, RANBP2, PML, PTPRN, CD44, JAK3, HLA-DRB5, CAMK2A | |
| GO:0070887 | Cellular response to cytokine stimulus | 0.0162 | 37 genesb | |
aThe raw P value for the GO analysis.
bThe gene identities are given in the Supplementary Material 1 along with the rest of the GO enrichment analysis results.